Endocannabinoid system protects against cryptogenic seizures.
نویسندگان
چکیده
Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.
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عنوان ژورنال:
- Pharmacological reports : PR
دوره 63 1 شماره
صفحات -
تاریخ انتشار 2011